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THE ROAD TO HEALTH . . . Using The Clark Method NewsletterJanuary/February 2004 Number 55 by Bonnie O’Sullivan
Upon receiving my copy (from England) of Christine Thorne’s newsletter, Infectious Diseases, Toxins and Natural Remedies early in March 2004, I read it immediately (to order her NL email Christine at chris@IDTNR.f9.co.uk). The articles about the silkworm-butterfly enzyme, Serrapeptase, which sounded so perfect for my daughter, Sandy, motivated me to call every health food store in the bay area looking for it. Only one store had it and within the hour I was on my way to San Francisco to make my purchase. That afternoon, Sandy and I began taking Serrapeptase tablets and she noticed a reduction in her whole-body-pain soon after taking her first tablet! By the next day (after only 3 tablets) Sandy’s deep chest cough was much better and her whole outlook on life had improved. Preventing a heart attack or stroke is my main reason for taking it so I didn’t expect a quick change; however, in 3 days I stopped craving dairy products (have I lost an allergy?). In this issue I have reprinted Christine’s collection of articles for you and made the highest quality Serrapeptase available to you through this newsletter (please see page 12). How A Tiny Chinese Silkworm Has The Power To Ease My AsthmaDaily Mail, November 12, 2002 (extracts): When keen athlete Stephen Kershaw was laid low by a bad bout of asthma he sought help from a treatment using the Chinese silkworm. Scientists have recently discovered that the tiny creature produces a unique enzyme, which has anti-inflammatory action. “I was wheezing a lot, producing a lot of phlegm and having difficulty breathing. It lasted 4 months and I just wasn’t able to get well. I was in a difficult position because I needed to go back on the oral steroids to improve my asthma but doing that would affect my diabetes.” Newcastle GP Dr. Kamal Anand offers alternative treatments as well as traditional. Dr. Anand suggested a remedy involving taking a capsule containing the silkworm enzyme. After a week Stephen’s condition had improved enough for him to put off going back on steroids. The enzyme Serrapeptase is made by bacteria that live in the gut of the silkworm and is secreted in its saliva. It has anti-inflammatory qualities that have been used in the treatment of arthritis. Serrapeptase eats away at the cocoon of the silkworm and eventually allows it to fly away as a butterfly. According to scientists the enzyme, which has only recently been isolated, attacks dead tissue, eating it up and also blocks chemicals that produce inflammatory responses. Besides feeling better Stephen’s lung capacity had improved. Dr. Anand had measured what is known as the peak flow reading. In a healthy teenager a score of 600 would be expected. Before becoming ill Stephen’s peak flow had topped 450 but had dropped to 380. “He was finding breathing quite an effort when he came to see me,” says Dr. Anand. “But there was significant improvement in his peak flow, which went back to over 400 within a short time. The enzyme in the Serrapeptase capsule has reduced the inflammation and has also eaten away at the phlegm, which was obstructing his breathing.” Buy LinkThe Worthy WormTherapy Weekly, September 2002 By David Potterton (extracts) Serrapeptase is said to digest non-living tissue such as blood clots, cysts and arterial plaque and to block the inflammatory process. There is a story of a young woman who suffered back pain for six years as the result of a motorcycle accident. But after taking Serrapeptase for only 10 days her pain disappeared. Apart from sports injuries and other causes of pain, the enzyme is being heralded as a treatment for conditions such as arthritis, fibromyalgia, chronic obstructive pulmonary disease, inflammatory bowel disease and even multiple sclerosis. Serrapeptase has been used in Asia and the Far East for over 25 years. A controlled trial in Germany studied the effect of Serrapeptase on ankle swelling caused by trauma. The study involved 66 patients treated surgically for rupture of the lateral ligament. They were randomized into three groups, one of which received Serrapeptase. In the group receiving the test substance postoperative swelling had decreased by 50% by the third postoperative day. In the other two groups (who had leg elevation and bed rest with and without the application of ice) no reduction in swelling had occurred at that time. (Editor’s Note: The study also included carpal tunnel syndrome patients.) Italian microbiologists say that biofilm formation is one of the most widespread mechanisms of bacterial resistance and a common cause of treatment failure in prosthetic device infections. They made various attempts to develop ways of inhibiting these biofilm-embedded bacteria. They found in seven different experiments that Serrapeptase greatly enhanced antibiotic activity and inhibited biofilm formation. The ability of Serrapeptase to remove mucous in conditions such as emphysema, Bronchiectasis [(pronounced bron-kee-ek’-tas-is) is a disorder of the airways within the lungs] and bronchitis may also be of interest. A team at the University of Naples evaluated the efficacy and tolerability of Serrapeptase in a multi center, double blind, placebo controlled study of 193 subjects suffering from acute or chronic ear nose or throat disorders. After three or four days significant symptom regression was observed in the Serrapeptase treated patients as compared to placebo. Hilary Freeman speaks to Lea Verity whose life has been transformed by SerrapeptaseDaily Express, February 5, 2002 (extracts): For more than 25 years Lea Verity suffered severe pain in her jaw and numbness in her face following a playground accident she had when she was just six. The accident caused damage to the tissues in her jaw, leading to inflammation around the joint, muscle spasms and a trapped nerve. The condition — TMJ (tempero-mandibular joint syndrome) — made it painful for her to eat or even smile. She spent many nights curled up in agony with a hot water bottle pressed to her face, as conventional pain killing tablets didn’t help. However, today Lea, 32, a sports center manager from Doncaster, Yorkshire, is completely free of pain. She has been taking SP-Zyme, a supplement containing the naturally occurring enzyme, Serrapeptase, for the past two months and her symptoms have disappeared almost overnight. Serrapeptase is already widely used in Europe, Japan and the US as an alternative to anti-inflammatory medications such as Aspirin, Ibuprofen and NSAIDS (non-steroidal anti-inflammatory drugs). Serrapeptase works by digesting tissue, such as scars, and blocking the chemicals that cause inflammation. This makes it an effective treatment for any condition caused by inflammation. Research in Germany and Japan has shown Serrapeptase can dissolve breast and ovarian cysts, ease symptoms of arthritis, speed the healing of torn ligaments and sports injuries, and aid post-operative healing. People with carpel tunnel syndrome or RSI, asthma, sinusitis, ear infections and migraine have also benefited from taking it. Recent studies show it helps to dissolve blood clots and arterial plaque, protects against strokes and shrinks varicose veins. It also appears to help cure infections by making antibiotics work more effectively. “Serrapeptase is useful in any disease or condition caused by dead tissue, mucous or clotted material,” says Jeannette Manning, a naturopathic nutritionist from San Diego, California, who has used the enzyme on many of her patients. “It dissolves damaged cells without harming healthy tissue, drains away mucous and, by blocking the chemicals that cause inflammation, stops pain.” Lea had given up any hope of recovery before she tried it. “I had what felt like a permanent earache and sometimes I’d get sharp, stabbing pains, which literally took my breath away,” she says. “The pain made me squint, affecting my eyesight and I couldn’t feel one side of my face. At its worst, it became impossible to open my jaw. I couldn’t even pry it open with my hands. “Neither doctors nor dentists knew how to help me. They implied my problems were psychological. All they could do was prescribe course after course of Ibuprofen, which made no difference. “Even when I was finally diagnosed with TMJ a year ago, which doctors can’t cure, my only options were strong painkillers and potentially risky surgery with a low success rate. I hated being dependant on painkillers and was getting unpleasant side-effects, such as indigestion pains and excess stomach acid. “After just a few days I started to notice an improvement,” she says. “The feeling in my face seemed to be coming back and the pain wasn’t as bad. After two weeks, I stopped taking Ibuprofen. I couldn’t believe it — I was pain-free, the stiffness in my jaw had gone and all the feeling in my face had returned. SP-Zyme achieved more in weeks than years of orthodontic treatment.” Lea’s life has changed dramatically since taking Serrapeptase. “I’ve reduced my dose and still have no symptoms,” she says. “My stomach problems have disappeared, and I haven’t noticed any side-effects at all and I feel more energetic.” Serrapeptase, The “Miracle” Microbial EnzymeHealthSavers.Info (extracts): Chances are you haven’t heard about Serrapeptase, the proteolytic enzyme, until now. It’s only been available as a nutritional supplement in the U.S. for the past two years. Yet for over 30 years, Serrapeptase has been gaining wide acceptance in Europe and Asia as a potent analgesic and anti-inflammatory drug. It’s been used to promote wound healing and surgical recovery. Recent Japanese patents even suggest that oral Serrapeptase may help treat or prevent such viral diseases as AIDS and hepatitis B and C. But perhaps its most spectacular application is in reversing cardiovascular disease. In fact, Serrapeptase appears so effective in unblocking carotid arteries that one researcher — Dr. Hans Nieper, the late, eminent internist from Hanover, Germany — called it a “miracle” enzyme. [Editor’s Note: Hans A. Nieper, M.D., an internist from Hannover, Germany studied the effects of Serrapeptase on plaque accumulations in the arteries. A book about Dr. Nieper’s work, The Curious Man: The Life and Works of Dr. Hans Nieper (Avery Penguin Putnam, December 1998), provides insight into his studies.] If this all sounds a little too miraculous to be true, read on. There’s a solid scientific rationale for each of these health benefits, and they all have to do with the fact that Serrapeptase is “proteolytic” — literally, protein dissolving. Proteolytic enzymes (also known as proteinases or peptidases) are ubiquitous in nature, being found in animals, plants, bacteria, and fungi. Human beings produce such well-known peptidases as trypsin and chymotrypsin to help digest our food, but we also generate countless others to control virtually every regulatory mechanism in our bodies. For example, various peptidases are involved in initiating blood clotting (thrombogenesis) and also in dissolving clots (fibrinolysis); in evoking an immune response and quelling it; and in both promoting and halting inflammation. The mechanism in each case is the ability of the enzyme to cut or cleave a protein target into two or more pieces, usually at very specific cleavage sites. The same mechanism makes it possible for peptidases to inactivate HIV, the AIDS-associated virus, by pruning the viral proteins necessary for infectivity. The medical use of enzymes as anti-inflammatory agents goes back many years. In the early 1950s it was discovered that intravenous trypsin could unexpectedly relieve the symptoms of many different inflammatory conditions, including rheumatoid arthritis, ulcerative colitis, and atypical viral pneumonia. Subsequently, intramuscular enzyme injections were found to be beneficial in counteracting post-surgical swelling (edema), treating thrombophlebitis and lower back strain, and rapidly healing bruises caused by sports injuries. At that time the mechanism of the anti-inflammatory effect remained obscure. Today it is believed to involve degradation of inflammatory mediators, suppression of edema, activation of fibrinolysis, reduction of immune complexes (antibody-antigen conglomerates), and proteolytic modification of cell-surface adhesion molecules which guide inflammatory cells to their targets.’ (Such adhesion molecules are known to play an important role in the development of arthritis and other autoimmune diseases.) It’s also thought that the analgesic effect of proteolytic enzymes is due to their cleavage of bradykinin, a messenger molecule involved in pain signaling. However, according to another theory, peptidases such as trypsin may be acting not as anti-inflammatory agents but rather as accelerants of the inflammatory process, thereby shortening its duration. Whatever the mechanism, many studies of proteolytic enzymes over the years have demonstrated their effectiveness in relieving pain and inflammation independently of steroids or non-steroidal anti-inflammatory drugs (NSAIDs). Fortunately we don’t need to rely on intramuscular injections any more to enjoy the benefits of proteolytic enzymes. Around 35 years ago researchers showed that enterically-coated enzymes such as trypsin, chymotrypsin or bromelain were orally active. Oral proteolytic enzymes have been used successfully ever since for inflammatory conditions. Recently the intestinal absorption of orally administered Serrapeptase has also been demonstrated. To achieve an ideal therapeutic effect, however, it is essential that any enzyme preparation be properly enterically coated so as to release the enzymes in the intestines (where they can be absorbed) and not in the stomach (where they can be digested). The proteolytic enzymes in common use today derive from bacteria (Serrapeptase grown from Serratia marcescens cultures), plants (bromelain from pineapple stem and papain from papaya), and animal sources (trypsin and chymotrypsin from hogs or cattle). They’re all generally useful, but for many applications Serrapeptase appears to be the most useful of them all. In one study Serrapeptase was compared to trypsin, chymotrypsin, and pronase (another microbial peptidase) in a rat model of scalding, which is known to induce abnormal activation of fibrinolysis. Serrapeptase was far more effective than any other enzyme in repressing fibrinolysis in this model, in agreement with its documented clinical efficacy as an anti-inflammatory agent. By the way, in case you’ve got a good eye for details, you might have noticed that a few paragraphs back we said the activation of fibrinolysis, not its repression, is one of the likely anti-inflammatory mechanisms of Serrapeptase. The truth is that Serrapeptase, like other peptidases, can have seemingly contradictory effects at different times under different circumstances. The essential point of the study just cited is that Serrapeptase and the other peptidases inhibited abnormal activation of fibrinolysis, and that this was a sign of their anti-inflammatory activity. In other circumstances Serrapeptase is definitely fibrinolytic, i.e., clot busting, and it is this property that makes it so useful in treating cardiovascular disease. According to Dr. Hans Nieper, only three 5 mg tablets of Serrapeptase daily for 12 to 18 months are sufficient to remove fibrous blockages from constricted coronary arteries, as confirmed in many of his patients by ultrasound examination. But that’s still not the whole story: Serrapeptase may well offer additional cardiovascular benefits not considered by Nieper. In particular, researchers have recently proposed that inflammation contributes to the development of arterial blockage. In one study, subjects with higher levels of CRP (C-reactive protein, a marker for systemic inflammation) were found to have a greater risk of future heart attack and stroke, independently of other risk factors such as smoking, high blood pressure, or cholesterol levels. Eighteen subjects with the highest levels of CRP who also used aspirin, however, showed dramatic decreases in their risk of heart attack, leading the researchers to speculate that the effectiveness of aspirin in preventing heart attack is due as much to its anti-inflammatory activity as to its anti-clotting effects. Serrapeptase, like aspirin, is both anti-inflammatory and anti-clotting; unlike aspirin, however, Serrapeptase can melt through existing fibrous deposits. Serrapeptase also lacks the serious gastrointestinal side effects associated with chronic use of NSAIDs such as aspirin. This combination of properties makes Serrapeptase just about the perfect remedy for warding off cardiovascular disease, better even than the proverbial aspirin a day. It’s beginning to look more and more as though Dr. Nieper was right — Serrapeptase is indeed a “miracle” enzyme. For optimal results in unclogging arteries Nieper suggests combining Serrapeptase with other nutritional factors, including bromelain, magnesium, carnitine, and selenium. To avoid possible pulmonary and ileal irritation, Nieper also recommends not exceeding a dose of about three tablets per day for long-term continuous use. Because Serrapeptase is a blood-thinning agent, it’s wise to consult your physician if you’re already taking any form of anticoagulant therapy (or, for that matter, if you suffer from any serious illness). Despite these cautions, however, Serrapeptase has an excellent tolerability profile in general. The Japanese company that first developed Serrapeptase, recommends up to six 5 mg tablets per day — two tablets three times a day, between meals for short-term treatment of acute inflammation due to surgery, wound healing, sinusitis, cystitis, bronchial asthma, bronchitis, and breast engorgement in lactating women. On a personal note, we are pleased to add our own anecdotal experience — Serrapeptase has come to our rescue three times in recent years, providing quick healing from two bike accidents and one car crash when we were rear-ended by an out-of-control auto. In each instance, six tablets a day were effective in relieving the pain and reducing the swelling. If you’re already taking proteolytic enzymes such as bromelain or trypsin for sports injuries, arthritis, multiple sclerosis, or any other condition including PMS, try adding or substituting Serrapeptase. You just might be amazed with the results. And if you’re not already taking proteolytic enzymes — what are you waiting for? There’s a miracle named Serrapeptase waiting to happen for you now. A Potent Proteolytic Enzymewww.vitasentials.com/serrazyme.htm (extracts) The inflammatory response is an important mechanism for protecting the body from attack by invading organisms and faulty cells. In the case of immune dysregulation, the body loses its ability to differentiate between innocuous and potentially dangerous substances. This defective mechanism results in a wide array of autoimmune diseases such as allergies, psoriasis, rheumatoid arthritis, ulcerative colitis, uveitis, multiple sclerosis and some cancers. Standard drug therapy for inflammatory-mediated diseases and trauma include steroids and non-steroidal anti-inflammatory agents (NSAIDs). Both classes of drugs offer temporary, symptomatic relief from swelling, inflammation and accompanying pain without treating the underlying condition. These drugs may also be immunosuppressive and cause dangerous side effects. The conscientious physician must weigh the benefits and long-term risks associated with the use of NSAIDs, especially in cases of rheumatoid arthritis. If left untreated, the inflammatory process itself can lead to limitation of joint function and destruction of bone, cartilage and articular structures. NSAIDs are among the most widely prescribed drugs for rheumatoid arthritis and other inflammatory joint conditions. Their effects are mediated through inhibition of the biosynthesis of prostaglandins. They work by irreversibly blocking cyclooxygenase, the enzyme that catalyzes the reactions of arachidonic acid to endoperoxide compounds. The neurological and gastrointestinal side effects of these agents have been reviewed in considerable detail. All of the NSAIDs, with the exception of Cytotec, inhibit prostaglandin El, a local hormone responsible for gastric mucosai cytoprotection. A common side effect from these medications is gastric ulcers. More serious adverse reactions such as blood dyscrasias, kidney damage and cardiovascular effects have been noted. Most physicians rotate among the ten most widely prescribed NSAIDs, as soon as one causes side effects or stops working. The search for a physiologic agent that offers anti-inflammatory properties without causing side effects may have ended with the discovery of the Serratia peptidase enzyme (Serrapeptase or SP). This anti-inflammatory agent is in wide clinical use throughout Europe and Asia as a viable alternative to salicylates, Ibuprofen (sold as an OTC in the U.S.) and the more potent NSAIDs. Unlike these drugs, SP is a naturally occurring, physiologic agent with no inhibitory effects on prostaglandins and devoid of gastrointestinal side effects. SP is an anti-inflammatory, proteolytic enzyme isolated from the microorganism, Serratia El5. This enzyme is naturally present in the silkworm intestine and is processed commercially today through fermentation. This immunologically active enzyme is completely bound to the alpha 2 macroglobulin in biological fluids. Histologic studies reveal powerful anti-inflammatory effects of this naturally occurring enzyme. The silkworm has a symbiotic relationship with the Serratia microorganisms in its intestine. The enzymes secreted by the bacteria in the silkworm’s intestine have a specific affinity to avital tissue and have no detrimental effect on the host’s living cells. By dissolving a small hole in the silkworm’s protective cocoon (avital tissue), the winged creature is able to emerge and fly away. The discovery of this unique biological phenomenon led researchers to study clinical applications of the SP enzyme in man. In addition to its widespread use in arthritis, fibrocystic breast disease and carpal tunnel syndrome, researchers in Germany have used SP for atherosclerosis. SP helps to digest atherosclerotic plaque without harming the healthy cells lining the arterial wall. Today, researchers consider atherosclerosis an inflammatory condition similar to other degenerative diseases. Some immunologists are even categorizing atherosclerosis as a benign tumor. Hardening and narrowing of the arterial wall is a cumulative result of microscopic trauma; inflammation occurs in the presence of oxidized lipids. SP doesn’t interfere with the synthesis of cholesterol in the body, but helps clear avital tissue from the arterial wall. It is important to note that cholesterol in its pure state is an antioxidant and a necessary component of the major organ systems in the body. The use of medications that block cholesterol biosynthesis may eventually damage the liver and compromise anti-oxidant status of the eyes, lungs and other soft tissues. While studies with SP in the treatment of coronary artery disease are relatively new, a wealth of information exists regarding its anti-inflammatory properties. SP has been used as an anti-inflammatory agent in the treatment of chronic sinusitis, to improve the elimination of bronchopulmonary secretions, traumatic injury (e.g. sprains and torn ligaments), post-operative inflammation and to facilitate the therapeutic effect of antibiotics in the treatment of infections. In the urological field, SP has been used successfully for cystitis and epididymitis. In a double-blind study, the anti-inflammatory enzyme, SP, was evaluated in a group of 70 patients with evidence of cystic breast disease. These patients were randomly divided into a treatment group and a placebo group. SP was noted to be superior to placebo for improvement of breast pain, breast swelling and in duration with 85.7% of the patients receiving SP reporting moderate to marked improvement. No adverse reactions were reported with the use of SP. The mechanisms of action of SP at the sites of various inflammatory processes consist fundamentally of a reduction of the exudative phenomena and an inhibition of the release of the inflammatory mediators. This peptidase induces fragmentation of fibrinose aggregates and reduces the viscocity of exidates, thus facilitating drainage of these products of the inflammatory response and thereby promoting the tissue repair process. Studies suggest that SP has a modulatory effect on specific acute phase proteins, which are involved in the inflammatory process. This is substantiated by a report of significant reductions in C3 and C4 complement, increases in opsonizing protein and reductions in concentrations of haptoglobulin, which is a scavenger protein that inhibits lysosomal protease. Carpal tunnel syndrome is a form of musculoligamentous strain caused by repetitive motion injury. Individuals who work at keyboard terminals are particularly susceptible to this condition. While surgery has been considered the first line treatment for carpal tunnel syndrome, recent studies reveal that the use of anti-inflammatory enzymes (e.g. SP and bromelain) in conjunction with vitamins B2 and B6 are also effective. In a study of chronic bronchitis, conducted by a team of otolaryngolosits, the SP-treated group showed excellent results compared with the placebo group in the improvement of loosening sputum, frequency of cough and expectoration. Other improvements included the posterior nasal hydrorhea and rhinostenosis. The administration of SP reduces the viscosity of the nasal mucus to a level at which maximal transport can be achieved. It has also been demonstrated that the simultaneous use of the peptidase and an antibiotic results in increased concentrations of the antibiotic at the site of the infection. SP digests non-living tissue, blood clots, cysts, and arterial plaque and inflammation in all forms. The late German physician Dr. Hans Nieper used serrapeptase to treat arterial blockage in his coronary patients. Serrapeptase protects against stroke and is more effective and quicker than EDTA chelation treatments in removing arterial plaque. He also reports that serrapeptase dissolves blood clots and causes varicose veins to shrink or diminish. Dr. Nieper told of a woman scheduled for hand amputation and a man scheduled for bypass surgery who both recovered quickly without surgery after treatment with serrapeptase. Several research groups have reported on the intestinal absorption of SP. SP is well absorbed orally when formulated with an enteric coating. It is known that proteases and peptidases are only absorbed in the intestinal area. These enzymes are mobilized directly to the blood and are not easily detectible in urine. Other enzymes with structural similarities have been reported to be absorbed through the intestinal tract. Chymotrypsin is transported into the blood from the intestinal lumen. Horseradish peroxidase can cross the mucosal barrier of the intestine in a biologically and immunologically active form. Several studies have appeared so far which refer to the systemic effects of orally given proteases and peptidases (e.g. SP), such as repression of edema and repression of blood vessel permeability induced by histamine or bradykinin. These enzymes also affect the kallikreinkinin system and the complement system, thus modifying the inflammatory response. In vitro and in vivo studies reveal that SP has an aspecific, anti-inflammatory effect, superior to that of other proteolytic enzymes. A review of the scientific literature, including a series of controlled, clinical trials with large patient groups, suggests that Serrapeptase is useful for a broad range of inflammatory conditions. If one considers the fact that anti-inflammatory agents are among the most widely prescribed drugs, the use of a safe, proteolytic enzyme such as SP would be a welcome addition to the physician’s armamentarium of physiologic agents. How Does Serrapeptase Work?From: Crohns.net (extracts) Serrapeptase, technically known as Serrato Peptidase, is a unique and very powerful proteolytic (protein digesting) enzyme. Specific bacteria found in the gut of silkworms and used to “digest” their cocoons manufacture it. Serrapeptase is now synthesized and sold for medicinal purposes in Europe and Japan under the registered name Danzen® and sold under a variety of names including, DanzenTM, AniflazymTM, and SerraZymeTM. In the US Serrapeptase is sold as a nutritional supplement. Most of the scientific research done on Serrapeptase has shown it to be a powerful antiinflammatory substance. It is used as an alternative to NSAID’s (non-steroidal anti-inflammatory drugs) for both rheumatoid and osteoarthritis. Serrapeptase also relieves pain and reduces swelling. Perhaps the most exciting benefit comes from the clinical application of Serrapeptase for cardiovascular problems. European physicians including the late Dr. Hans Nieper, successfully used Serrapeptase to reduce the levels of arterial plaque and improve blood flow and cardiac function. Serrapeptase reduces inflammation in three ways: 1. Breaks down the insoluble protein by-products of blood coagulation known as fibrin. 2. Thins the fluids formed from inflammation or injury and facilitates their drainage which speeds the tissue repair process. 3. Serrapeptase alleviates pain by inhibiting the release of specific pain-inducing amines known as bradykinin. The cardiovascular effects are due to the remarkable ability to break down dead or damaged tissue without harming living tissue. Atherosclerotic plaques can be slowly dissolved without harming the inside of the arteries. Who Should Use Serrapeptase?If you have an inflammatory condition like arthritis, sinusitis, fibrocystic breasts or you regularly take pain medication such as aspirin or NSAID’s then a trial with Serrapeptase is highly recommended. If you have known cardiovascular disease then it is prudent to discuss Serrapeptase with your physician so that your progress can be monitored. If a decision is made to use Serrapeptase, it can be used in conjunction with EDTA chelation therapy and may enhance the outcome. At least 10 mg of Serrapeptase daily is recommended for anyone over the age of 40 years who is interested in preventing arterial plaques. How Much Serrapeptase Should You Use?The recommended dose range for Serrapeptase is 10-30 mg per day. For prevention, 10 mg daily. For arthritis, sinusitis, fibrocystic breast, bronchitis, and cardiovascular problems, 20 mg daily. For pain use 10-20 mg daily, starting with 10 mg and working up to 20 mg daily. For injury, trauma or post surgery recovery use 30 mg daily for 2 days then drop to 20 mg daily until swelling and pain is resolved. Conclusion:As we age we experience some profound alterations in the flesh, blood and bones that make up our bodies. Age brings potential inflammation, pain, arterial deposits and a host of other unwelcome changes. It is not often that a compound like Serrapeptase becomes available that can legitimately address so many health concerns. This enzyme is very powerful in very small doses and relatively inexpensive. We highly recommend a 3 month trial for anyone over the age of 40 years. Safety:We have two cautions about the use of Serrapeptase. Gastrointestinal irritation can occur in elderly individuals with long-term use. It is rare but it has occurred. There is also a possibility of increased susceptibility to infection of the lung with using Serrapeptase. This is also rare but is thought to be the result of the ability of Serrapeptase to thin mucus secretions. In most cases this is a highly beneficial response, but caution is advised especially if you have a history of lung problems. Serrapeptase (SP) is Now Available from RTHSerrapeptase is a nutritional supplement containing 5 mg of the purified enzyme, Serratio Peptidase (Serrapeptase or SP), in an enterically-coated tablet. Serrapeptase is anti-inflammatory, anti-edemic, breaks down fibrous masses, and acts rapidly. It can reduce swelling from injury or surgery and swelling due to water retention; it increases penetration of antibiotics into living tissue. The fibrinolytic properties of this enzyme suggest its use for destroying sclerotic plaques in arteries — there have been anecdotal reports of success, but so far no formal clinical trials. Because of its anti-inflammatory capabilities, Serrapeptase is often considered an alternative to salicylates and NSAIDS. It is also an effective treatment for the symptoms of acute or chronic ear, nose and throat disorders. Serrapeptase must be taken on an empty stomach: After eating wait 1½ to 2 hours to take Serrapeptase and after taking Serrapeptase wait 20-30 minutes before eating (i.e. take it one half hour before meals.) Place your order now: Call (800) 651-7080 or go to www.road-to-health.com on the Internet. Serrapeptase/Emphysema Radio InterviewBy Dennis Gore, Pharmacist and Radio Broadcaster on the BBC, August 2004 Question: When did you first come across the Serrapeptase? Dennis Gore: I basically met Serrapeptase in about March 2002 as a result of the publicity surrounding the good results people were getting and the fact that it was available on prescription from doctors in Germany and other European countries. I researched it and found out that it was an enzyme made by a bacterium and was originally found in the Silkworm. The Silkworm uses the enzyme to help digest the tough Mulberry leaves it lives on and spectacularly it uses it to instantly dissolve a large hole in the super hard wall of the cocoon it lives in. The Silkworm moth then emerges quickly and escapes before predators can devour it. I found out that scientists in about 1970 started to culture this enzyme in the laboratory by feeding it a protein. The results were a dry white, tasteless powder that contains the Serrapeptase Enzymes. They then did some exploration research by giving it to animals and eventually, humans. They found it was perfectly safe, with no side effects and so they set up properly conducted double blind studies. These showed that as well as getting rid of chronic inflammation they would also dissolve non-vital protein material. I read about Dr. Hans Napier’s results with cleared blocked arteries and preventing the need for by-pass operations. I read studies from around the world where mucus and catarrh could be cleared very easily, swelling and trauma recovery and (recover of) even non-cancerous breast cysts. In fact, after mentioning this on my radio program, a lady telephoned me from Southport and reported that after using this for breast cysts, her doctor had given her the all clear. The first dramatic effect that I experienced was with a man in his 60’s who had been a heavy smoker for many years. His wife wheeled him from a special van into my pharmacy. He was very breathless in his voice and was difficult to understand because he has emphysema and chronic obstructive pulmonary disease (COPD). These are considered to cause irreversible damage to the linings of the lungs usually caused by smoking or toxic environments. Whereas asthma may be considered reversible, COPD is an irreversible disease. Normally with this, the only thing we can do is relieve or help, say with an oxygen tank or sprays to open the airways, or steroid sprays that help to stop inflammation. This man said he had heard me on the BBC Radio Program talking about the studies, saying that it had helped to maintain the airways of people with breathing problems by helping to breakdown the damaged tissue that had built up over their lifetime, whether due to smoking or things like working with chemicals. He told me he was on sprays, on oxygen and on antibiotics every two weeks as he was always getting bad infections and breathlessly he told me wanted to try Serrapeptase. To begin with, he took two 20,000 IU tablets (equivalent to 5 mg tablets) on an empty stomach, four times per day. Later he reduced it to four per day of the tablets and finally, as maintenance, he reduced it to a couple per day. Three weeks later the door opened and this man, who I had only met once sitting in a wheelchair (just one of the many daily faces in my practice), walked in and said in a completely clear voice, with no breathlessness, “Do you remember me? I was in three weeks ago with my wife.” I had to apologize that I see so many people and could he remind me. He then reminded me that he was the person with emphysema and this 6’ tall person who had been in a wheelchair previously, had marched out of his van, no wife with him, no wheelchair with him and spoke to me in a clear voice. He told me that in the early days so much rubbish was coming up that he thought his lungs might be disintegrating, but he soon realized that it was a big clearout underway. He started to feel so much better and he was no longer on antibiotics, no longer on oxygen cylinders, and he was no longer using his sprays. He was still smoking and he had booked a holiday to go to Benidorm, in Spain in March 2002. He is still a regular visitor to the shop to get supplies; he brings other people along, he buttonholes other people in the shop and praises Serrapeptase if he hears them ask about it. He is still so thrilled after 2 years of feeling good. Asbestosis and SerrapeptaseFrom www.nhsdirect.nhs.uk and Robert Redfern Asbestosis is a serious, long-term lung disease caused by inhaling asbestos dust over a prolonged period. Asbestos is a naturally occurring fiber that was widely used for various industrial purposes, such as insulation and shipbuilding until the mid 1980s. Since then the health effects of asbestos have become clear and the supply and use of asbestos and asbestos products has been banned for all but a few exceptions by the Asbestos (Prohibition) Regulations. People working in industries where asbestos was used extensively (such as demolition work, plumbing, and at power stations) were likely to have been exposed to breathing in fibers of asbestos often over a period of years. Changes in the lung occur slowly — asbestosis can take 20 years or more to develop — so ill effects were not instantly traceable to asbestos. Asbestosis is one of a number of conditions that can be caused by exposure to asbestos. Other related conditions include mesothelioma (a malignant tumor in the lung) and benign pleural thickening (the lining of the lung is thickened and hardened). At least 3500 people in Great Britain die each year from mesothelioma and asbestos related lung cancer as a result of past exposure to asbestos. How can Serrapeptase help?Serrapeptase helps immensely as it clears out all of the inflammation, mucus and dead/scar tissue. By clearing away this problem tissue it enables the body’s own healing system to replace it with healthy tissue and better lung function as a result. How many Serrapeptase tablets should I take?Start with 3 tablets of Serrapeptase 3 times (X) per day on an empty stomach. If no relief in 7 days, increase it to 4 tablets 3 X per day. Then gradually reduce it to 1 tablet 1 X per day. Serrapeptase Asbestosis Testimonial“I can’t tell you what a difference those tablets have made to this household,” smiles Mrs. Maher. “They’ve kept the disease at bay. Without them he just wouldn’t be here.” —Wife of Asbestosis Suffer More Serrapeptase TestimonialsIn part from: http://smart-drugs.net/Serrapeptase-testimonial.htm Serrapeptase Testimonial #1Just thought I would let you know how impressed I am with your Serrapeptase supplement. Having a hip defect, I suffer from arthritis and have been in a great deal of pain for the past few years. I tried Serrapeptase after reading a newspaper article, and was amazed at the results. After just a couple of days, the inflammation in my joints had reduced, and I am now pain-free. I have been able to reduce my prescription drugs from 18 a day to 2, and I can walk normally for the first time in years, which I am really grateful for as I’m still only 34! My friends cannot believe the difference, and some have been trying Serrapeptase for themselves — all with successful results. I will definitely be placing another order. Yours sincerely, Janine Harper, Great Britian PS You can reprint my letter. I hope that other people find Serrapeptase as beneficial as I have. I finally have my life back after years of suffering with pain. Serrapeptase Testimonial #2With regard to the effects of Serrapeptase: I initially decided to try it because of an article in the UK national press reporting on its benefits as an anti-inflammatory agent. It is available in the UK , but at twice the cost advertised in America . I have suffered from inflammation due to wear and tear and a compressed disc in the lower back for six years now, and have had to rely on NSAIDS for relief. I don’t like taking them because of possible long-term side effects. I find that Serrapeptase is more effective than NSAID in this respect. However, it so happens that there is a history of heart disease in my family (from both parents), and whilst I have no symptoms, it is comforting to know that Serrapeptase may well be removing any build-up of arterial plaque. I can only assume that doctors here do not prescribe it in Britain because of the lack of wholescale testing results. It also happens that I am mildly asthmatic (I sound like a walking, talking hospital case), and for as long as I can remember, I have suffered from nasal blockage on one side or the other. This has dramatically reduced and more often than not, vanished, since I started to use Serrapeptase. I have noticed no side effects. I have no objection to you showing this to your customers. Jim Westhead, Great Britian Serrapeptase Testimonial #3Your comment and observation on Serrapeptase was interesting as in March this year I fell through an open trap in the floor of my house badly injuring myself. I suffered from shock and had to lie down for an hour but in the absence of any apparent hemorrhaging I opted not to seek medical attention. It looks today as if I’ve misshaped a couple of ribs and the blow was such that I should have had signs of bruising and swelling yet none appeared! Although I suffered the tenderness for months I was otherwise not incapacitated, with the exception, however, that I was unable to continue weight training for some time. In early November, on losing my balance (would those incidents be due to ageing?), I fell headlong hitting and splitting my forehead on the sharp edge of the sewing machine box and with my 14.5 stones behind it! I was concussed for a few seconds and bleeding yet was able to resume my normal daily activities. The open wound on my forehead healed faster than any open wound ever healed before; indeed within about 5 days it had entirely gone! The frontal lobe area of my brain was obviously injured and I suffered internal aches, occasional dizziness, and problems with focusing, and those were much in evidence if and whenever I omitted to take my daily dose of Serrapeptase. I’m fit and well, and indeed, there’s seldom a day when I never have that ‘feel good’ factor! I’ve been taking Serrapeptase regularly for over 4 years and hence the interest in your observation about Serrapeptase. Regards and best wishes, Robert Scotland Place your order now: Call (800) 651-7080 or go to www.road-to-health.com on the Internet. Serrapeptase Testimonial #4I have already sent you one report on the effectiveness of Serrapeptase, relating my own experience. At my recommendation, a neighbor (a lady of 60+ years) who has suffered for many years from very heavy catarrh, asked me to order a couple of bottles from you. She has been delighted by the results, which have resulted in a dramatic improvement in her symptoms within two weeks of starting to take 4 pills a day. Jim Westhead, Great Britian Serrapeptase Testimonial #5In late 1996, I had a carotid sonogram as part of a general health workup. Although I was symptom free, I have a lousy family history. Three of my grandparents died of vascular disease (56, 56, and 63) and both of my parents had cardiovascular disease. My mother died of an MI at 62. At the time of this exam, I was 51 and had gone through extensive EDTA chelation therapy for heavy metal toxicity and life extension. Since there was no baseline before the carotid scan, we’ll never know how much or if any improvement had come from the chelation. The result of the ‘96 test showed 12% occlusion on the left side, and 14% occlusion on the right with 24% occlusion at the fork on the right. These atherosclerotic lesions were very apparent, showing up as long, bumpy, irregular white ridges on the computer scan of the carotids. My doctor at the time said that this wasn’t enough occlusion to be clinically important, but that he wanted to keep an eye on it to make sure that it wasn’t progressing. At that time I was already on an aggressive life-extension program, including diet, exercise, and megavitamin intake (well, the conventional docs call it “megavitamin,” but to me it just seems like reasonable intake). Over the intervening 18 months, I only changed four things that could reasonably be expected to have had an effect on atherosclerotic plaques in place: 1. I went on the Sears “zone” diet (loosely) aiming to take macronutrients in a 30-30-40 ratio (protein, fat, carbohydrates). This was a fairly relaxed dietary change. 2. Based on a Linus Pauling recommendation for atherosclerosis, I added three 500 mg lysine tablets to each meal’s supplements (I was already taking 10 to 13 grams of vitamin C per day, Pauling’s other recommendation). Why not? Cheap, simple, and almost no chance of toxicity — and who wants to bet he’s smarter than Linus Pauling? 3. I went on an aggressive anti-homocysteine program (last 12 months only) adding folic acid, B6, and trimethyl glycine to each meal’s supplements, and a sublingual B12 dot morning and evening. 4. I went on Serrapeptase, two 5 mg tablets on an empty stomach upon arising and again upon retiring. Here are some things I did NOT do: 1. I continued to eat red meats more or less as I wanted to — maybe 2 to 3 times a week. 2. I made no attempt to avoid cholesterol (high cholesterol is, I suspect, a symptom of vascular disease, not a cause). 3. I made no attempt to avoid natural fats in my diet. Although I prefer olive oil, I eat butter and cook with lard or other natural saturated fats. I DO NOT eat synthetically hydrogenated fats, avoiding all margarines, Crisco and similar shortenings, and anything with “partially hydrogenated” on the label. This June (1998) I went for a second carotid scan after a change of health plans and doctors. The results were completely clear on both sides. No signs of any plaque, not even streaking. Now, I am aware that it’s impossible to ascribe cause and contribution in a single case history. And it’s probable that everything I did, including the years of chelation before the first test, made a contribution to my remarkable (well, I think complete regression in 18 months is remarkable) result. But I strongly suspect that the Big Thing in my program was the Serrapeptase. Certainly the Sears diet, the lysine and the anti-homocysteine measures could be expected to contribute to halting the progress of disease. But I cannot imagine how anything but the Serrapeptase could have so quickly and dramatically removed the atherosclerotic plaques. Some disclaimers. I am not a physician. I have presented a personal case history as honestly and completely as I can. In no way is this a recommendation of anything for anybody. I take no responsibility for anything that happens to anybody who tries all or part of my program with or without advice of a physician. In other words, this is what I did for me, your mileage may vary, and your health is your responsibility to screw up or improve on your own. But if I were giving advice, I’d say to talk to your physician before launching into any big change. (Of course, if your doctor becomes horrified at the thought that you might have an actual idea concerning your own health, maybe you should have a talk with yourself about the type of physician you’ve picked.) Finally, a note for any conventional physician who might be reading this and tich tiching over my playing doctor on myself. You have a point. No one should be his own lawyer or physician, not even someone who’s degreed in the subject. And I confess that (even though I always try to work with a longevity doc) it can get lonely out here trying to decide what’s best for my own health. But when I consider the alternatives you guys offer me — neck surgery or expensive cholesterol-lowering drugs with ugly side effects — I like my program. I sure got better results. AB, Southern California Serrapeptase Testimonial #6Serrapeptase Clears Up White Spots & Makes Skin Soft Again For 10 years my arms, legs and face had white spots that would bleed if I picked them off. Dr. Kelley thought it could be Uremic Frost, which is usually caused by kidney failure. My kidney’s seemed to be fine, but the spots did look like uric acid crystals (needlelike crystals of sodium uric acid that contribute to kidney stones and gout). It seemed I had developed white spots on my skin instead of developing kidney stones or gout. I first noticed the spots in 1994 after switching to Gold Stake mineral capsules, which are inorganic. I had taken chelated (inorganic minerals bonded to a protein) minerals since 1961 (to prevent osteoporosis), but a friend recommended Gold Stake. When I stopped taking Gold Stake the spots went away, but a few months later they came back. After stopping the Gold Stake minerals I had gone back to taking my regular chelated mineral tablets. Then, in 2000, I switched to Water Oz liquid, angstrom size minerals and the spots began to disappear. By March of this year (2004), the spots had disappeared from my face and arms, but were still on my legs. That’s when I began taking Serrapeptase tablets, the enzyme that eats away at the cocoon of the Chinese silkworm and eventually allows it to fly away as a butterfly. Taken by you and I, in synthetic-tablet form, it attacks dead tissue, eating it up (not harming our living tissue) and also blocks chemicals that produce inflammatory responses. After 3 months of taking 2 Serrapeptase tablets 2-3 times a day the spots completely disappeared! Now, for a month, I’ve just been taking 1 tablet 2 times a day and the spots have not returned. I’m taking it for my arteries and, as a bonus; I have soft skin again! Bonnie O'Sullivan Serrapeptase References l.. Kee WH. Tan SL, Lee V. Salmon YM. The treatment of breast engorgement with Serrapeptase (Danzen): a random ized double-blind controlled trial. Singapore Med J. 1989:30(1):48-54. 2. M izukoshi, D. et al. A double-blind clinical study of serrapeptase in the treatment of chronic sinusitis. Igaku Ayrni 109:50-62.1979. 3. Carratu, L. et al. Physio-chemical and rheological research on mucolytic activity of serrapeptase in chronic broncho-pneumopathies. Curr. Ther. Res. 28(6):937-951. 1980. 4. Braga , P.C. et al. Effects of serrapeptase on muco-ciliary clearance in patients with chronic bronchitis. Curr. Ther. Res. 29(5):738-744,1981. 5. Mazzonie, A. et al. Evaluation of serrapeptase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind randomized trial versus placebo. J. int. Med. Res. 18(5):379-388,1990. 6. Kakinumu, A. et al. Regression of fibrinolysis in scalded rats by administration of serrapeptase. Biochem. Pharmacol. 31:2861-2866,1982. 7. Marly, M. Enzymotherapie anti-inflammatoire a l'aide de la serrapeptase: resultats cliniques en traumatologie et en ORL. C RTherapeut. 3:9-19,1985. 8. Odagiri, J. et al. Clinical applications of serrapeptase in sinusitis. Med. Consult. New Remedy 6:201-209, 1979. 9. Yamazaki, J. et al. Anti-inflammatory activity of TSP , a protease produced by a strain of Serratia. Folia Pharmacol. Japon. 6^302-314,1967. I0. Harad~, Y. Clinical efficacy of serrapeptase on buccal swelling after radical operation for chronic sinusitis. Igaku Ayumi 123:768-778.1982. 1 I. Matsudo , A. et at. Effect of serrapeptase (Danzen) on inflammatory edema following operation for thyropid disease. Med. Consult. New Remedy 18:171-175, 1981. 12. Fujitani, T. et al. Effect of anti-inflammatory agent on transfer of antibiotics to the maxillary sinus mucosa in chronic sinusitis. Otorhinolaryngol. Clin. North Am. 66:557-565. 1976. 13. Tago. T. and Mitsui, S. Effects of serrapeptase in dissolution of sputum, especially in patients with bronchial asthma. Jap. Clin. Exp. Med. 49:222-228, 1972. 14. Mazzonie, A. et al. Evaluation of serrapeptase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind randomized trial versus placebo. J. int. Med. Res. 18(5):379-388,1990. 15. Kase, Y. et al. A new method for evaluating mucolytic expectorant activity and its application. II. Application to two proteolytic enzymes, serrapeptase and seaprose. Arzneimittelforschung 32:374-378,1982. 16. Marriott, C. Modification of the rheoloaical properties of mucus by drugs. Adv. Exp. Med. Biol. 144^75-84, 1982. 17. Majima. Y. et al. Effects of orally administered drugs on dynamic viscoelasticity of human nasal mucus. Am. Rev. Respit. Dis. 141:79-83.1990. 18. Miyata, K. Intestinal absorption of serrapeptase. J ApplBiochem. 1980:2:111-16. 19. Aso T. et al. Breast engorgement and its treatment: Clinical effects of Danzen (serrapeptase) an anti-inflammatory enzyme preparation. The world of Obstetrics and Gynecology (Japanese). 1981:33:371-9. 20. Esch PM, Gemgross H. Fabian A. Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with serrapeptase-a prospective study (German). FortschrMed. 1989; 107(4):67-8, 71-2. 21. Majima Y, lnagaki M, Hirata K. Takeuchi K, M orishita A, Sakakura Y. The effect of an orally administered proteolytic enzyme on the elasticity and viscosity of nasal mucus. Arch Otorhinolaryngol. 1988;244(6):355-9. 22. Selan L, Berlutti F, Passariello C. Comodi-Ballanti MR, Thaller MC. ?roteolytic enzymes: a new treatment strategy for prosthetic infections? Antimicrob Agents Cheroother. 1993; 37(12):2618-21. 23. Koyama A, Mori J, Tokuda H, Waku M, Anno H, Katayama T, Murakami K, Komatsu H, Hirata M, Arai T, et al. Augmentation by serrapeptase of tissue permeation by cefotiam (Japanese). Jpn JAntibiot. 1986; 39(3):761-71. We have had great success with this product: Please Select Your Preference below: Serrapeptase, 1 bottle, 100 tablets: $17.99 plus $7.50 shipping (Total: $25.49) After you click on one of the choices above a new window will open looking similar to the image below.
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TestimonialsJust wanted you to know that I received my order of serrapeptase on Tuesday March 1st, and wanted you to know what is happening already! I've taken 2 - 5mg tabs twice a day to help with the acute sinusitis that I have had since I was a child. Also, earlier this year I was diagnosed with histoplasmosis in my lungs (due to having the chicken pox at age 33 which got inflamed during a recent bout of bronchitis). |
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The Material in this Web Site is for educational purposes only and is not intended as a prescription for any illness. [Home] [Privacy Policy] [Terms of Use] [Contact Us (Help Desk)] The Road to Health, Inc. 800-651-7080 Out of USA 623-242-2460 Fax: 800-868-7298 
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